|?|| (C;C) (C;G) (G;G) ||28|
] Authors of this study of just 189 subjects conclude that rs3740199 polymorphism may affect occurrence of knee osteoarthritis
and its progression (p = 0.018), and even speculate that this SNP's effect is "remarkably gender-dependent and anatomical site-specific". Of course, another alternative is that it's just another case of overinterpretation based on having too few samples for a properly powered SNP study. Only time will tell.
[PMID 16385451] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
|| not reviewed
|| Insufficiently evaluated not reviewed
[PMID 23491141] Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study
[PMID 23606964] Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population
[PMID 25667922] Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population
[PMID 26553447] ADAM33 and ADAM12 genetic polymorphisms and their expression in Egyptian children with asthma