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rs3740199

From SNPedia

Orientationplus
Stabilizedplus
Make rs3740199(C;C)
Make rs3740199(C;G)
Make rs3740199(G;G)
ReferenceGRCh38 38.1/142
Chromosome10
Position126330456
GeneADAM12
is asnp
is mentioned by
dbSNPrs3740199
ebirs3740199
HLIrs3740199
Exacrs3740199
Varsomers3740199
Maprs3740199
PheGenIrs3740199
hapmaprs3740199
1000 genomesrs3740199
hgdprs3740199
ensemblrs3740199
gopubmedrs3740199
geneviewrs3740199
scholarrs3740199
googlers3740199
pharmgkbrs3740199
gwascentralrs3740199
openSNPrs3740199
23andMers3740199
23andMe allrs3740199
SNP Nexus

SNPshotrs3740199
SNPdbers3740199
MSV3drs3740199
GWAS Ctlgrs3740199
GMAF0.4518
Max Magnitude
? (C;C) (C;G) (G;G) 28
[PMID 19268722] Authors of this study of just 189 subjects conclude that rs3740199 polymorphism may affect occurrence of knee osteoarthritis and its progression (p = 0.018), and even speculate that this SNP's effect is "remarkably gender-dependent and anatomical site-specific". Of course, another alternative is that it's just another case of overinterpretation based on having too few samples for a properly powered SNP study. Only time will tell.

[PMID 16385451OA-icon.png] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.


GET Evidence
ADAM12-G48R
aa_change Gly48Arg
aa_change_short G48R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.576036
summary



[PMID 23491141] Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: A genetic association study


[PMID 23606964OA-icon.png] Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population


[PMID 25667922OA-icon.png] Analysis of Single Nucleotide Polymorphisms within ADAM12 and Risk of Knee Osteoarthritis in a Chinese Han Population


[PMID 26553447] ADAM33 and ADAM12 genetic polymorphisms and their expression in Egyptian children with asthma