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rs4607517

From SNPedia

Orientationplus
Stabilizedplus
Make rs4607517(A;A)
Make rs4607517(A;G)
Make rs4607517(G;G)
ReferenceGRCh38 38.1/141
Chromosome7
Position44196069
is asnp
is mentioned by
dbSNPrs4607517
ebirs4607517
HLIrs4607517
Exacrs4607517
Varsomers4607517
Maprs4607517
PheGenIrs4607517
hapmaprs4607517
1000 genomesrs4607517
hgdprs4607517
ensemblrs4607517
gopubmedrs4607517
geneviewrs4607517
scholarrs4607517
googlers4607517
pharmgkbrs4607517
gwascentralrs4607517
openSNPrs4607517
23andMers4607517
23andMe allrs4607517
SNP Nexus

SNPshotrs4607517
SNPdbers4607517
MSV3drs4607517
GWAS Ctlgrs4607517
GMAF0.1648
Max Magnitude
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 19060907OA-icon.png]
Trait Fasting plasma glucose
Title Variants in MTNR1B influence fasting glucose levels
Risk Allele A
P-val 1E-25
Odds Ratio 0.06 [0.05-0.07] mmol/l increase


[PMID 19741166OA-icon.png] Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)


GWAS snp
PMID [PMID 20081858OA-icon.png]
Trait Fasting glucose-related traits
Title New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Risk Allele A
P-val 2E-16
Odds Ratio None None


[PMID 20839289OA-icon.png] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose


[PMID 21036910OA-icon.png] Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study

OMIM613219
Desc
Variant
Relatedalso
[PMID 21887289OA-icon.png] Glucose-Raising Genetic Variants in MADD and ADCY5 Impair Conversion of Proinsulin to Insulin


[PMID 22096510OA-icon.png] Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a chinese population

GWAS snp
PMID [PMID 22508271OA-icon.png]
Trait
Title Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).
Risk Allele G
P-val 1E-7
Odds Ratio 1.1500 None


[PMID 19096518OA-icon.png] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.


[PMID 20043853OA-icon.png] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.


[PMID 20870969OA-icon.png] Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study.


[PMID 21278902OA-icon.png] Genetic risk profiling for prediction of type 2 diabetes.

GWAS snp
PMID [PMID 22581228OA-icon.png]
Trait
Title A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
Risk Allele
P-val 8E-56
Odds Ratio None None


GET Evidence
rs4607517
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.203125
summary



[PMID 23029294OA-icon.png] Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus


[PMID 22698489OA-icon.png] Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.


[PMID 23462794OA-icon.png] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.


[PMID 26577716] 10-year trajectory of β-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study