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rs4958803

From SNPedia

Orientationplus
Stabilizedplus
Make rs4958803(C;C)
Make rs4958803(C;G)
Make rs4958803(G;G)
ReferenceGRCh38 38.1/141
Chromosome5
Position155414920
is asnp
is mentioned by
dbSNPrs4958803
ebirs4958803
HLIrs4958803
Exacrs4958803
Varsomers4958803
Maprs4958803
PheGenIrs4958803
hapmaprs4958803
1000 genomesrs4958803
hgdprs4958803
ensemblrs4958803
gopubmedrs4958803
geneviewrs4958803
scholarrs4958803
googlers4958803
pharmgkbrs4958803
gwascentralrs4958803
openSNPrs4958803
23andMers4958803
23andMe allrs4958803
SNP Nexus

SNPshotrs4958803
SNPdbers4958803
MSV3drs4958803
GWAS Ctlgrs4958803
GMAF0.3994
Max Magnitude
? (C;C) (C;G) (G;G) 28

This SNP was identified as a "core" SNP helping to define one (of nine total) runs of homozygosity (ROH) potentially associated with increased risk for schizophrenia. Each region consists of at least 100 consecutive SNPs, generally spanning 500KB or more, for which both chromosomes in an individual were homozygous. The overall odds ratio for schizophrenia associated with inheriting 1, 2, or 3 of these 9 ROHs was calculated to be 3.3, 5.4, or 24, respectively, with 95% confidence intervals of (1.9-5.7), (3.7-16.1), and (6.9-83.9), respectively.[PMID 18077426OA-icon.png]

This particular SNP, rs4958803, was deemed to be the core SNP of a region on chromosome 5 with 116 SNPs spanning 440KB from 5:154592379 to 5:155033077 (build 35). Potentially independent of the ROH, the risk allele for this SNP in the orientation as displayed in HapMap v21a is (G).[PMID 18077426OA-icon.png]