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rs4986938

From SNPedia

Orientationminus
Stabilizedminus
Make rs4986938(A;A)
Make rs4986938(A;G)
Make rs4986938(G;G)
ReferenceGRCh38 38.1/141
Chromosome14
Position64233098
GeneESR2
is asnp
is mentioned by
dbSNPrs4986938
ebirs4986938
HLIrs4986938
Exacrs4986938
Varsomers4986938
Maprs4986938
PheGenIrs4986938
hapmaprs4986938
1000 genomesrs4986938
hgdprs4986938
ensemblrs4986938
gopubmedrs4986938
geneviewrs4986938
scholarrs4986938
googlers4986938
pharmgkbrs4986938
gwascentralrs4986938
openSNPrs4986938
23andMers4986938
23andMe allrs4986938
SNP Nexus

SNPshotrs4986938
SNPdbers4986938
MSV3drs4986938
GWAS Ctlgrs4986938
GMAF0.2718
Max Magnitude
? (A;A) (A;G) (G;G) 28

[PMID 19298602] Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians.


[PMID 19111408OA-icon.png] Association of estrogen receptor 2 gene polymorphisms with obesity in women (obesity and estrogen receptor 2 gene)

[PMID 19473078] Estrogen receptor Beta gene variant is associated with vascular dementia in elderly women


[PMID 19386104OA-icon.png] Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study

[PMID 19032032OA-icon.png] Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women



[PMID 19654868OA-icon.png] Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer


[PMID 20390341] A systematic review of the relationship between polymorphic sites in the estrogen receptor-beta (ESR2) gene and breast cancer risk

[PMID 19739075] Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy

[PMID 20172949OA-icon.png] Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China



[PMID 20399928] Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma.


[PMID 22678799] [Association between estrogen receptor beta gene polymorphisms in Chinese Uygur patients and intrahepatic cholestasis of pregnancy]


[PMID 22759347OA-icon.png] Association of estrogen receptor beta variants and serum levels of estradiol with risk of colorectal cancer: a case control study


[PMID 22701696OA-icon.png] Genetic Polymorphisms Influence the Ovarian Response to rFSH Stimulation in Patients Undergoing In Vitro Fertilization Programs with ICSI


[PMID 16118344OA-icon.png] Polymorphisms in the estrogen receptor beta (ESR2) gene are associated with bone mineral density in Caucasian men and women.


[PMID 17935138OA-icon.png] Haplotypes of the estrogen receptor beta gene and breast cancer risk.


[PMID 17941906] Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease.


[PMID 18053221OA-icon.png] Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study.


[PMID 18487282] Association between ESR2 genetic variants and risk of myocardial infarction.


[PMID 18592033OA-icon.png] Sex steroid-related candidate genes in psychiatric disorders.


[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 19337586OA-icon.png] Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?


[PMID 19438492] Estrogen receptor polymorphisms and the risk of endometrial cancer.


[PMID 19555469OA-icon.png] A prospective study of androgen levels, hormone-related genes and risk of rheumatoid arthritis.


[PMID 19754929OA-icon.png] Effects of two common polymorphisms in the 3' untranslated regions of estrogen receptor beta on mRNA stability and translatability.


[PMID 19927160] Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women.


[PMID 20080857] Endothelial function, but not carotid intima-media thickness, is affected early in menopause and is associated with severity of hot flushes.


[PMID 20655613OA-icon.png] Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women.


[PMID 20961965] Differential association of juvenile and adult systemic lupus erythematosus with genetic variants of oestrogen receptors alpha and beta.


[PMID 21429951] Quantitative trait analysis suggests polymorphisms of estrogen-related genes regulate human sperm concentrations and motility.


[PMID 21762042] Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis.


[PMID 21804148OA-icon.png] Oestrogen receptor polymorphisms and late-life depression.


[PMID 22011627] Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART.


[PMID 22155094OA-icon.png] Gender differences in the IL6 -174G>C and ESR2 1730G>A polymorphisms and the risk of Parkinson's disease.


[PMID 22183267] Association of estrogen receptor beta gene polymorphisms with vascular dementia in women.


[PMID 22228197] Estrogen receptors alpha (rs2234693 and rs9340799), and beta (rs4986938 and rs1256049) genes polymorphism in prostate cancer: Evidence for association with risk and histopathological tumor characteristics in Iranian men.


[PMID 22324545] Are polymorphisms in oestrogen receptors genes associated with lipid levels in response to hormone therapy?


[PMID 22463697] Association of polymorphisms in the estrogen receptor beta (ESR2) with unexplained recurrent spontaneous abortion (URSA) in Chinese population.


GET Evidence
rs4986938
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.331195
summary



[PMID 23686919] Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction


[PMID 23274843] Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms


[PMID 22906475] The ESR2 AluI 1730G>A (rs4986938) gene polymorphism is associated with fibrinogen plasma levels in postmenopausal women.


[PMID 25128001OA-icon.png] Polymorphisms in estrogen receptors predict the risk of male infertility: a meta-analysis


[PMID 25973102OA-icon.png] Single nucleotide polymorphisms of ERβ and coronary atherosclerotic disease in Chinese Han women


[PMID 26590813] ESR1 and ESR2 polymorphisms in the BIG 1-98 trial comparing adjuvant letrozole versus tamoxifen or their sequence for early breast cancer