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rs6696981

From SNPedia

Orientationplus
Stabilizedplus
Make rs6696981(G;G)
Make rs6696981(G;T)
Make rs6696981(T;T)
ReferenceGRCh38 38.1/141
Chromosome1
Position22376365
is asnp
is mentioned by
dbSNPrs6696981
ebirs6696981
HLIrs6696981
Exacrs6696981
Varsomers6696981
Maprs6696981
PheGenIrs6696981
hapmaprs6696981
1000 genomesrs6696981
hgdprs6696981
ensemblrs6696981
gopubmedrs6696981
geneviewrs6696981
scholarrs6696981
googlers6696981
pharmgkbrs6696981
gwascentralrs6696981
openSNPrs6696981
23andMers6696981
23andMe allrs6696981
SNP Nexus

SNPshotrs6696981
SNPdbers6696981
MSV3drs6696981
GWAS Ctlgrs6696981
GMAF0.1809
Max Magnitude
? (G;G) (G;T) (T;T) 28
rs6696981 increases susceptibility to Bone mineral density variations, lower for carriers of the G allele [PMID 18445777]

rs6696981 increases susceptibility to Osteoporotic fractures for carriers of the G allele [PMID 18445777]

GWAS snp
PMID [PMID 19079262]
Trait Bone mineral density (spine)
Title New sequence variants associated with bone mineral density
Risk Allele G
P-val 2E-8
Odds Ratio 0.12 [0.08-0.16] SD decrease



[PMID 22824048] Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women


[PMID 19181680OA-icon.png] Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.


[PMID 19629617OA-icon.png] Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.


[PMID 20554715] Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.


GET Evidence
rs6696981
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.195312
summary