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rs744166

From SNPedia

Orientationminus
Stabilizedminus
Make rs744166(C;C)
Make rs744166(C;T)
Make rs744166(T;T)
ReferenceGRCh38 38.1/141
Chromosome17
Position42362183
GeneSTAT3
is asnp
is mentioned by
dbSNPrs744166
ebirs744166
HLIrs744166
Exacrs744166
Varsomers744166
Maprs744166
PheGenIrs744166
hapmaprs744166
1000 genomesrs744166
hgdprs744166
ensemblrs744166
gopubmedrs744166
geneviewrs744166
scholarrs744166
googlers744166
pharmgkbrs744166
gwascentralrs744166
openSNPrs744166
23andMers744166
23andMe allrs744166
SNP Nexus

SNPshotrs744166
SNPdbers744166
MSV3drs744166
GWAS Ctlgrs744166
GMAF0.4541
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS
SNP rs744166
PubMedID [PMID 18587394OA-icon.png]
Condition Crohn's disease
Gene STAT3
Risk Allele A
pValue 7.00E-012
OR 1.18
95% CI


OMIM612380
DescINFLAMMATORY BOWEL DISEASE 22; IBD22
Variant
Relatedalso


[PMID 19776189] Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults


[PMID 20109474] Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population


[PMID 20159113OA-icon.png] Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene


[PMID 20222910] Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children

OMIM126200
Desc
Variant
Relatedalso


[PMID 22205606] JAK2 and STAT3 polymorphisms in a Han Chinese Population with Behcet's disease


[PMID 22269120] Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease


[PMID 15657875OA-icon.png] Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.


[PMID 18978678OA-icon.png] Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.


[PMID 19068216OA-icon.png] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.


[PMID 19557189OA-icon.png] Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.


[PMID 19653082OA-icon.png] Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population.


[PMID 19915572OA-icon.png] Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.


[PMID 20179083] No association between myeloproliferative neoplasms and the Crohn's disease-associated STAT3 predisposition SNP rs744166.


[PMID 20200543] STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility.


[PMID 20405052OA-icon.png] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.


[PMID 20454450OA-icon.png] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.


[PMID 21304977OA-icon.png] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.


[PMID 22065112] The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.


[PMID 22095036] Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.


GET Evidence
rs744166
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.523438
summary



[PMID 23127549] Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease


[PMID 23611997] JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population


[PMID 24081513OA-icon.png] Association of single-nucleotide polymorphisms in the STAT3 gene with autoimmune thyroid disease in Chinese individuals


[PMID 24864251OA-icon.png] rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population


[PMID 25132422] An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer


[PMID 26186918OA-icon.png] STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer


[PMID 26204395] Single nucleotide polymorphisms in the STAT3 gene influence AITD susceptibility, thyroid autoantibody levels, and IL6 and IL17 secretion