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TPH1

From SNPedia
(Redirected from TPH)

is agene
is mentioned by
Full nametryptophan hydroxylase 1
Other namesTPH
EntrezGene7166
PheGenI7166
VariationViewer7166
ClinVarTPH1
GeneCardsTPH1
dbSNP7166
SADR7166
HugeNav7166
wikipediaTPH1
googleTPH1
gopubmedTPH1
EVSTPH1
HEFalMpTPH1
MyGene2TPH1
23andMeTPH1
UniProtP17752
EnsemblENSG00000129167
OMIM191060
# SNPs7
 Max MagnitudeChromosome positionSummary
rs17999131.118,025,708heroin addiction in hispanics
rs180053218,026,269
rs210897718,019,049
rs21110518,033,757
rs62358018,042,430
rs68430218,038,806
rs793350518,024,440

rs211105, rs1800532 and rs7933505 related to schizophrenia

[PMID 14681922] and suicidal behavior

TPH1 is the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum. Expression of TPH1 is inhibited by [1] LRP5. It has been observed that this decreased serotonin blood level normalizes bone formation and bone mass in LRP5-deficient mice.