Have questions? Visit https://www.reddit.com/r/SNPedia

TYMS

From SNPedia

is agene
is mentioned by
Full namethymidylate synthetase
EntrezGene7298
PheGenI7298
VariationViewer7298
ClinVarTYMS
GeneCardsTYMS
dbSNP7298
SADR7298
HugeNav7298
wikipediaTYMS
googleTYMS
gopubmedTYMS
EVSTYMS
HEFalMpTYMS
MyGene2TYMS
23andMeTYMS
UniProtP04818
EnsemblENSG00000176890
OMIM188350
# SNPs15
 Max MagnitudeChromosome positionSummary
rs1001761662,103
rs1059394672,792
rs16430673,444
rs16948305668,465
rs2612100672,363
rs2790673,086
rs2847149666,371
rs2853533658,064
rs2853539659,829
rs2853542657,685
rs34489327673,451
rs34743033657,646
rs45445694657,646
rs502396659,236
rs699517673,016


The TYMS gene encodes the enzyme thymidylate synthase, which is the primary target of 5-fluorouracil as used in chemotherapeutic treatment of various cancers. Variations in the the TYMS gene can influence risk for toxicity, including:

  • rs16430, in the 3' UTR of the gene; a 6bp insertion/deletion polymorphism
  • rs45445694, a 28bp VNTR
  • rs34743033, a G>C SNP in 2nd repeat of 3R allele