User:Ysearcher

From SNPedia

Public Genome
Summary	23andMe

Promethease	report
Summary
Platform

I am a 56 year old American male of entirely colonial era British Isles ancestry. Currently sharing with about 140 participants at 23andMe - three out of five of my "highest overall" matches using the "Compare Genes" tool (autosomal DNA only) are natives & current residents of the United Kingdom. My Y chromosome haplogroup is R-L21* ("short naming convention", per ISOGG phylogenetic tree), & my maternal grandfather's Y hg is also R-L21*. My mitochondrial DNA haplogroup is T2b2 & my father's mtDNA hg is V. I have had various & sundry DNA tests performed by Family Tree DNA, DNA Heritage, Relative Genetics, the Sorenson Molecular Genealogy Foundation (SMGF), Trace Genetics & 23andMe (no conflicts found in any test results from these multiple sources). A preponderance of evidence gathered from 30+ years of genealogical research & about 5 years of genomic research suggests that my ancestry is "mostly" from the areas bordering Hadrian's wall & the Irish Sea, but with substantial ancestry from East Anglia as well. One ancestor claimed native American ancestry at the Dawes Commission hearings in Oklahoma circa 1902, but no substantiation of this claim has ever been confirmed. Several males with whom I share common ancestry (we have common links in our pedigrees) are all derived for M269.

My extended family medical history is fairly typical for an American male of my ancestry, with heart disease, stroke, & various cancers being the major risk factors. My direct paternal line has a very well documented history of serious heart disease, but my father is now 90 years old without any known heart problems. As genomic testing continues to flourish & improve, I hope to use my test results to improve my lifestyle choices, diet & behavior. This could include many facets of health care, as well as advance planning for the end of life.

Ultimately, I believe that this technology will prove useful in reducing the explosive costs of health care for the developed world, an issue that is rapidly approaching crisis levels. Reducing health care cost is a balance between predicting therapy that is appropriate & *therapy that is not appropriate*. Without those constraints, healthcare becomes a consumer driven "free for all" contest. There are large areas of the economy that may benefit from that approach, but it can only have profoundly detrimental effects on society in the long term. Very high health care costs are a serious impediment to the growth of future generations. There is no cure for aging & death - we need to learn to accept it gracefully when necessary, versus trying to buy every day that we can at any cost.