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XRCC1

From SNPedia

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23andMeXRCC1
# SNPs13
 Max MagnitudeChromosome positionSummary
rs1261108843,568,650
rs17997821.443,553,422
rs230716643,544,178
rs2548643,551,746
rs25487243,551,574
rs25489043,552,260
rs268258543,577,136
rs285450143,555,849
rs285450943,570,445
rs321324543,575,535
rs321325543,573,355
rs3213337043,557,785
rs91592743,553,075


The XRCC1 gene encodes a DNA repair gene, and polymorphisms in DNA repair genes have been studied particularly for their relation to cancer risk.

SNPs in XRCC1 include:


One particular study of salivary gland carcinomas (SGC) reports:

  • The XRCC1 1915C allele was associated with a lower SGC risk, and the XRCC1 rs1799782 194Trp allele was associated with a higher SGC risk. Multivariate analysis demonstrated that individuals who had the 1915 polymorphic homozygous CC genotype (OR, 0.4, CI: 0.2-0.9, p=.017) had a significantly lower risk of SGC, and individuals who had the Arg194Trp heterozygous CT genotype (OR, 1.6, CI: 1.0-2.6, p=.059) had a higher, borderline significant risk. The CGTTGG haplotype was associated with a higher SGC risk (OR, 3.5, CI: 1.1-11.3, p=.036).[PMID 17559126]