Rs25489

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is asnp
is mentioned by
dbSNPrs25489
hapmaprs25489
hgdprs25489
ensemblrs25489
gopubmedrs25489
scholarrs25489
googlers25489
pharmgkbrs25489
hgvbaseg2prs25489
medrefsnprs25489
23andMers25489
SNP Nexus

GeneXRCC1
Chromosome19
Orientationminus
Position48748251
GenotypeEffect
rs25489(A;A)4.68x higher risk for breast cancer
rs25489(A;G)normal risk
rs25489(G;G)normal risk


Genotypes Magnitude Summary
Rs25489(A;A) 4.68x higher risk for breast cancer
Rs25489(A;G) normal risk
Rs25489(G;G) 00 normal risk

rs25489, a SNP also known as Arg280His located in the DNA-repair gene XRCC1, is associated with an increased risk for breast cancer based on a study of 1,100 Cypriot women. The odds ratio for the rs25489(A;A) homozygote is 4.68, CI: 1.01-21.7, p=0.03.[PMID 18188695]

rs25489(A;G) prostate cancer patients being treated by radiation therapy are more likely (67% compared to 24%, p=0.048) to develop erectile dysfunction after irradiation than (G;G) patients, based on a study of 135 patients.[PMID 18582155]

Neighborrs25487
Distance686
? (A;G) (G;G)


[PMID 17767850] Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer: a case-control study


[PMID 19707910] Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis

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