rs1061646
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | 1.16x increased risk for breast cancer |
| (C;T) | 1.08x increased risk for breast cancer | |
| (T;T) | normal risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 16 |
| Position | 89739569 |
| Gene | FANCA, ZNF276 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1061646 |
| dbSNP (classic) | rs1061646 |
| ClinGen | rs1061646 |
| ebi | rs1061646 |
| HLI | rs1061646 |
| Exac | rs1061646 |
| Gnomad | rs1061646 |
| Varsome | rs1061646 |
| LitVar | rs1061646 |
| Map | rs1061646 |
| PheGenI | rs1061646 |
| Biobank | rs1061646 |
| 1000 genomes | rs1061646 |
| hgdp | rs1061646 |
| ensembl | rs1061646 |
| geneview | rs1061646 |
| scholar | rs1061646 |
| rs1061646 | |
| pharmgkb | rs1061646 |
| gwascentral | rs1061646 |
| openSNP | rs1061646 |
| 23andMe | rs1061646 |
| SNPshot | rs1061646 |
| SNPdbe | rs1061646 |
| MSV3d | rs1061646 |
| GWAS Ctlg | rs1061646 |
| GMAF | 0.4775 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 18056155] breast cancer rs1061646 was associated with risk in the initial study (p=0.0052), and in the replication studies (p=0.032). In a combined analysis, (8,556 cases, 9,605 controls) this SNP yielded an 8% increase in risk per allele. Note that this analysis was carried out in a multi-ethnic study, and rs1061646 showed more consistent association with risk in non-Caucasian populations.
[PMID 18701435
] Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.
| ClinVar | |
|---|---|
| Risk | Rs1061646(T;T) |
| Alt | Rs1061646(T;T) |
| Reference | Rs1061646(C;C) |
| Significance | Non-pathogenic |
| Disease | not specified |
| Variation | info |
| Gene | ZNF276 FANCA |
| CLNDBN | not specified |
| Reversed | 1 |
| HGVS | NC_000016.9:g.89805977G>A |
| CLNSRC | |
| CLNACC | RCV000242351.1, |
