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rs10865331

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.4 1.4x higher risk for ankylosing spondylitis
(A;G) 1.2 1.2x higher risk for ankylosing spondylitis
(G;G) 0 normal risk ankylosing spondylitis
ReferenceGRCh38 38.1/141
Chromosome2
Position62324337
is asnp
is mentioned by
dbSNPrs10865331
dbSNP (classic)rs10865331
ClinGenrs10865331
ebirs10865331
HLIrs10865331
Exacrs10865331
Gnomadrs10865331
Varsomers10865331
LitVarrs10865331
Maprs10865331
PheGenIrs10865331
Biobankrs10865331
1000 genomesrs10865331
hgdprs10865331
ensemblrs10865331
geneviewrs10865331
scholarrs10865331
googlers10865331
pharmgkbrs10865331
gwascentralrs10865331
openSNPrs10865331
23andMers10865331
SNPshotrs10865331
SNPdbers10865331
MSV3drs10865331
GWAS Ctlgrs10865331
GMAF0.4201
Max Magnitude1.4
? (A;A) (A;G) (G;G) 28


rs10865331 is a SNP in chromosomal region 2p15.

After initial GWAS reports linked this SNP to ankylosing spondylitis (AS), a follow-up study in 456 Spanish patients replicated the association between the rs10865331(A) allele and higher risk for AS (p = 0.039).

In a 2010 report, the AA genotype was associated with 1.3x odds of ankylosing spondylitis, and the GG genotype with 0.8x odds, compared to the AG genotype. [PMID 20062062OA-icon.png]

GWAS snp
PMID [PMID 20062062OA-icon.png]
Trait Ankylosing spondylitis
Title Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
Risk Allele A
P-val 2E-19
Odds Ratio 1.27 [1.18-1.37]
OMIM106300
Desc
Variant
Relatedalso
GWAS snp
PMID [PMID 21743469OA-icon.png]
Trait
Title Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Risk Allele A
P-val 7E-34
Odds Ratio None None


[PMID 22138694] A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis


[PMID 20810504] Association of the intergenic single-nucleotide polymorphism rs10865331 (2p15) with ankylosing spondylitis in a Spanish population.


[PMID 21041274] Genetic studies of ankylosing spondylitis in Koreans confirm associations with ERAP1 and 2p15 reported in white patients.


[PMID 21068102] Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese.

GWAS snp
PMID [PMID 23128233OA-icon.png]
Trait Crohn's disease
Title Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
Risk Allele A
P-val 1E-9
Odds Ratio 1.10 [1.062-1.134]


[PMID 27909141] Developing a Risk-scoring Model for Ankylosing Spondylitis Based on a Combination of HLA-B27, Single-nucleotide Polymorphism, and Copy Number Variant Markers.


[PMID 28493913OA-icon.png] Pathogenic variants screening in seventeen candidate genes on 2p15 for association with ankylosing spondylitis in a Han Chinese population.


[PMID 31523044] Analysis of 47 non-MHC Ankylosing Spondylitis Susceptibility Loci Reveals Shared Associated Variants across Caucasians and Han Chinese.


[PMID 31994481] rs10865331 in 2p15 increases susceptibility to ankylosing spondylitis: a HuGE review and meta-analysis.