rs1271572
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | normal | |
| (G;T) | 1.65x increased risk only in men for myocardial infarction | |
| (T;T) | 1.65x increased risk only in men for myocardial infarction; 1.8x increased risk in females for ovarian cancer |
| Reference | GRCh38 38.1/141 |
| Chromosome | 14 |
| Position | 64295199 |
| Gene | ESR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1271572 |
| dbSNP (classic) | rs1271572 |
| ClinGen | rs1271572 |
| ebi | rs1271572 |
| HLI | rs1271572 |
| Exac | rs1271572 |
| Gnomad | rs1271572 |
| Varsome | rs1271572 |
| LitVar | rs1271572 |
| Map | rs1271572 |
| PheGenI | rs1271572 |
| Biobank | rs1271572 |
| 1000 genomes | rs1271572 |
| hgdp | rs1271572 |
| ensembl | rs1271572 |
| geneview | rs1271572 |
| scholar | rs1271572 |
| rs1271572 | |
| pharmgkb | rs1271572 |
| gwascentral | rs1271572 |
| openSNP | rs1271572 |
| 23andMe | rs1271572 |
| SNPshot | rs1271572 |
| SNPdbe | rs1271572 |
| MSV3d | rs1271572 |
| GWAS Ctlg | rs1271572 |
| GMAF | 0.455 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 18487282] The rs1271572(T) allele was significantly more common in patients who developed MI (P < 0.001), based on a study of 710 Spanish patients. This was statistically significant only in men [odds ratio 1.65, CI: 1.18-2.30; p = 0.003).
[PMID 18704709
] Based on a study of 313 female patients, rs1271572(T;T) homozygotes were at increased risk for epithelial ovarian cancer. The odds ratio was 1.79, CI:1.15-2.79, p global = 0.01.
[PMID 19111408] Association of estrogen receptor 2 gene polymorphisms with obesity in women (obesity and estrogen receptor 2 gene)
[PMID 19032032] Associations of the estrogen receptors 1 and 2 gene polymorphisms with the metabolic syndrome in women
[PMID 19739075] Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy
[PMID 22511967] Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India
[PMID 16083630] [Association between single-nucleotide polymorphisms in estrogen receptor beta gene and risk of prostate cancer].
[PMID 18053221] Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study.
[PMID 18304720] Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.
[PMID 18579753] Vascular actions of estrogens: functional implications.
[PMID 19337586] Do Estrogen Receptor beta Polymorphisms Play A Role in the Pharmacogenetics of Estrogen Signaling?
[PMID 19654868] Genetic polymorphisms of estrogen receptors alpha and beta and the risk of developing prostate cancer.
[PMID 22970307] Potential Role of Estrogen Receptor Beta as a Tumor Suppressor of Epithelial Ovarian Cancer
[PMID 23711151] Significance of rs1271572 in the estrogen receptor beta gene promoter and its correlation with breast cancer in a southwestern Chinese population
