rs13010627

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	0	common in clinvar

Make rs13010627(A;A)

Make rs13010627(A;G)

Reference

GRCh38 38.1/141

Chromosome

2

Position

201209375

Gene

CASP10

is a	snp
is	mentioned by
dbSNP	rs13010627
dbSNP (classic)	rs13010627
ClinGen	rs13010627
ebi	rs13010627
HLI	rs13010627
Exac	rs13010627
Gnomad	rs13010627
Varsome	rs13010627
LitVar	rs13010627
Map	rs13010627
PheGenI	rs13010627
Biobank	rs13010627
1000 genomes	rs13010627
hgdp	rs13010627
ensembl	rs13010627
geneview	rs13010627
scholar	rs13010627
google	rs13010627
pharmgkb	rs13010627
gwascentral	rs13010627
openSNP	rs13010627
23andMe	rs13010627
SNPshot	rs13010627
SNPdbe	rs13010627
MSV3d	rs13010627
GWAS Ctlg	rs13010627

Merged from

Rs17860404

GMAF

0.02847

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

Previous studies had suggested that the minor allele of this SNP might influence breast cancer. However, a 2009 European study of 30,000 breast cancer cases, compared to 30,000 controls, found no association, or as they put it, "persuasive evidence against an overall association between invasive breast cancer risk and (this SNP)".[PMID 19423537]

OMIM	603909
Desc
Variant
Related	also

ClinVar
Risk	rs13010627(A;A)
Alt	rs13010627(A;A)
Reference	Rs13010627(G;G)
Significance	Probable-non-pathogenic
Disease	Autoimmune lymphoproliferative syndrome
Variation	info
Gene	CASP10
CLNDBN	Autoimmune lymphoproliferative syndrome
Reversed	0
HGVS	NC_000002.11:g.202074098G>A
CLNSRC	GeneReviews
CLNACC	RCV000279231.1,

[PMID 10412980] Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.

[PMID 23212337] Role of CASP-10 gene polymorphisms in cancer susceptibility: a HuGE review and meta-analysis