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rs2242446

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common in clinvar
Make rs2242446(C;T)
Make rs2242446(T;T)
ReferenceGRCh38 38.1/141
Chromosome16
Position55656513
GeneSLC6A2
is asnp
is mentioned by
dbSNPrs2242446
dbSNP (classic)rs2242446
ClinGenrs2242446
ebirs2242446
HLIrs2242446
Exacrs2242446
Gnomadrs2242446
Varsomers2242446
LitVarrs2242446
Maprs2242446
PheGenIrs2242446
Biobankrs2242446
1000 genomesrs2242446
hgdprs2242446
ensemblrs2242446
geneviewrs2242446
scholarrs2242446
googlers2242446
pharmgkbrs2242446
gwascentralrs2242446
openSNPrs2242446
23andMers2242446
SNPshotrs2242446
SNPdbers2242446
MSV3drs2242446
GWAS Ctlgrs2242446
GMAF0.2635
Max Magnitude0
? (C;C) (C;T) (T;T) 28


[PMID 20863575] Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD


[PMID 15722184] Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorder.


[PMID 17630229] Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroups.


[PMID 18081710OA-icon.png] Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.


[PMID 18779921] The combined effect of norepinephrine transporter gene and negative life events in major depression of Chinese Han population.


[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.


[PMID 21412203OA-icon.png] Genetic variation in the presynaptic norepinephrine transporter is associated with blood pressure responses to exercise in healthy humans.


[PMID 23442739] Psychomotor depressive symptoms may differentially respond to venlafaxine


[PMID 23648227] Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis.


[PMID 25990886] Impact of monoamine-related gene polymorphisms on hippocampal volume in treatment-resistant depression


[PMID 26051731] Association study between 5-HT2A and NET gene polymorphisms and recurrent major depression disorder in Chinese han population


[PMID 26508020] Potential involvement of NET polymorphism in serotonin/norepinephrine reuptake inhibitor response in panic disorder


ClinVar
Risk rs2242446(T;T)
Alt rs2242446(T;T)
Reference Rs2242446(C;C)
Significance Probable-non-pathogenic
Disease Orthostatic intolerance
Variation info
Gene SLC6A2
CLNDBN Orthostatic intolerance
Reversed 0
HGVS NC_000016.9:g.55690425C>T
CLNSRC
CLNACC RCV000264953.1,



[PMID 32339102] Age-dependent association of polymorphisms in the promoter and 5'-untranslated region of the norepinephrine transporter gene with generalized anxiety disorder.


[PMID 33340618] Association between genetic variants of the norepinephrine transporter gene (SLC6A2) and bipolar I disorder.