[PMID 18252792] rs1053049, rs6902123, and rs2267668 in PPARD affect Lifestyle Intervention induced changes in overall adiposity, hepatic fat storage, and relative muscle mass. Our findings provide a mechanistic explanation for the involvement of these genetic variations in the development of insulin resistance and type-2 diabetes.
| OMIM | 600409 |
| Desc | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-DELTA; PPARD |
| Variant | |
| Related | also |
| OMIM | 604517 |
| Desc | PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA, COACTIVATOR 1, ALPHA; |
| Variant | |
| Related | also |
[PMID 19681917] The role of genetic variation in peroxisome proliferator-activated receptors in the polycystic ovary syndrome (PCOS): an original case-control study followed by systematic review and meta-analysis of existing evidence
[PMID 17327385] Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention.
[PMID 21331343
] The myocyte expression of adiponectin receptors and PPARdelta is highly coordinated and reflects lipid metabolism of the human donors.
[PMID 23186209] Mitochondriogenesis genes and extreme longevity.
] The myocyte expression of adiponectin receptors and PPARdelta is highly coordinated and reflects lipid metabolism of the human donors.
