rs2395185
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 2 | 1.33x increased risk of Ulcerative Colitis, but much lower Type 1 Diabetes risk. |
| (G;T) | 2 | 2.72x higher risk of Type 1 Diabetes, but 0.88x lower risk of Ulcerative Colitis. |
| (T;T) | 3 | 9.49x risk of Type 1 Diabetes, but 0.58x lower risk of Ulcerative Colitis. |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 32465390 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2395185 |
| dbSNP (classic) | rs2395185 |
| ClinGen | rs2395185 |
| ebi | rs2395185 |
| HLI | rs2395185 |
| Exac | rs2395185 |
| Gnomad | rs2395185 |
| Varsome | rs2395185 |
| LitVar | rs2395185 |
| Map | rs2395185 |
| PheGenI | rs2395185 |
| Biobank | rs2395185 |
| 1000 genomes | rs2395185 |
| hgdp | rs2395185 |
| ensembl | rs2395185 |
| geneview | rs2395185 |
| scholar | rs2395185 |
| rs2395185 | |
| pharmgkb | rs2395185 |
| gwascentral | rs2395185 |
| openSNP | rs2395185 |
| 23andMe | rs2395185 |
| SNPshot | rs2395185 |
| SNPdbe | rs2395185 |
| MSV3d | rs2395185 |
| GWAS Ctlg | rs2395185 |
| GMAF | 0.292 |
| Max Magnitude | 3 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
A genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry, concluded that this SNP and several others were associated with altered risk for the disease.[PMID 19122664
]
[PMID 19837788] Capture of type 1 diabetes-susceptible HLA DR-DQ haplotypes in Japanese subjects using a tag single nucleotide polymorphism
| GWAS snp | |
|---|---|
| PMID | [PMID 19915573] |
| Trait | Ulcerative colitis |
| Title | A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population |
| Risk Allele | G |
| P-val | 5E-22 |
| Odds Ratio | 1.92 [1.68-2.19] |
[PMID 22286212] Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein-Barr Virus Status-Defined Subgroups
[PMID 19128478] Complex nature of SNP genotype effects on gene expression in primary human leucocytes.
[PMID 20017995] A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies.
[PMID 20018015] Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis.
[PMID 20018024] On the association between rheumatoid arthritis and classical HLA class I and class II alleles predicted from single-nucleotide polymorphism data.
[PMID 20018025] Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium.
[PMID 20018075] Genome-wide association study of rheumatoid arthritis by a score test based on wavelet transformation.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
[PMID 21304891] A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22383892] Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
| GWAS snp | |
|---|---|
| PMID | [PMID 23143601]
|
| Trait | Lung cancer |
| Title | Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. |
| Risk Allele | T |
| P-val | 1E-8 |
| Odds Ratio | 1.17 [1.11-1.23] |
[PMID 22694930] Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
[PMID 24707947] Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk
[PMID 29191591] Fine-mapping the MHC region in Asian populations identified novel variants modifying susceptibility to lung cancer.
