rs244715 is a SNP on chromosome 5.
A case control study of ~2,000 women found that each rs244715(T) allele was associated with an average increase in age at menopause of ~1 month. This also meant that each rs244715(C) allele yielded an odds ratio of 1.2 (CI: 1.09–1.32, p = 1.7 x 10e-4) of early menopause, defined as occurring before the age of 46.[PMID 20952801
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Overall, women homozygous for the "early" alleles at all 4 SNPs found in this study were ~4 times more likely to undergo menopause early compared to women who had a total of 3 or less risk alleles. However, the ability to predict which women will actually undergo early menopause using these 4 SNPs is still low.[PMID 20952801]
[PMID 33497044] Genetic Determinants of Premature Menopause in A Mashhad Population Cohort.
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