rs288326

plus

Geno	Mag	Summary
(G;G)	0	common in complete genomics

Make rs288326(A;A)

Make rs288326(A;G)

Reference

GRCh38 38.1/141

Chromosome

2

Position

182838608

Gene

FRZB

is a	snp
is	mentioned by
dbSNP	rs288326
dbSNP (classic)	rs288326
ClinGen	rs288326
ebi	rs288326
HLI	rs288326
Exac	rs288326
Gnomad	rs288326
Varsome	rs288326
LitVar	rs288326
Map	rs288326
PheGenI	rs288326
Biobank	rs288326
1000 genomes	rs288326
hgdp	rs288326
ensembl	rs288326
geneview	rs288326
scholar	rs288326
google	rs288326
pharmgkb	rs288326
gwascentral	rs288326
openSNP	rs288326
23andMe	rs288326
SNPshot	rs288326
SNPdbe	rs288326
MSV3d	rs288326
GWAS Ctlg	rs288326

GMAF

0.05464

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

OMIM	605083
Desc	OSTEOARTHRITIS OF HIP, FEMALE-SPECIFIC, SUSCEPTIBILITY TO
Variant	0002
Related	also

[PMID 19479880 ] Meta-analysis of 14 studies did not support a significant association between rs288326 and osteoarthritis.

[PMID 22095095] Variant alleles of the WNT antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis

ClinVar
Risk	rs288326(A;A)
Alt	rs288326(A;A)
Reference	Rs288326(G;G)
Significance	Other
Disease	Osteoarthritis susceptibility 1
Variation	info
Gene	FRZB
CLNDBN	Osteoarthritis susceptibility 1
Reversed	0
HGVS	NC_000002.11:g.183703336G>A
CLNSRC	OMIM Allelic Variant UniProtKB (protein)
CLNACC	RCV000005531.2,

[PMID 15210948 ] Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

[PMID 17237116 ] Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis.

[PMID 19961594 ] Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study.

[PMID 20043861 ] No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.

[PMID 22544526 ] Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.