rs356220

plus

Geno	Mag	Summary
(C;C)
(T;T)	1.5	increased risk of Parkinson's Disease

Reference

GRCh38 38.1/141

Chromosome

4

Position

89720189

Gene	LOC105377329

0.4219

1.5

(C;C) (C;T) (T;T)

28

GWAS snp
PMID	[PMID 20711177 ]
Trait
Title	Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Risk Allele	T
P-val	3E-11
Odds Ratio	1.38 [1.25-1.52]

GWAS snp
PMID	[PMID 21084426]
Trait
Title	Genome-wide association study confirms BST1 and suggests a locus on 12q24 as risk loci for Parkinson's disease in the European population
Risk Allele	T
P-val	3E-8
Odds Ratio	1.3700 [NR]

GWAS snp
PMID	[PMID 21044948 ]
Trait
Title	Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21
Risk Allele	A
P-val	9E-16
Odds Ratio	1.2700 [1.17-1.37]

GWAS snp
PMID	[PMID 21738487 ]
Trait
Title	Web-based genome-wide association study identifies two novel Loci and a substantial genetic component for Parkinson's disease.
Risk Allele	T
P-val	2E-19
Odds Ratio	1.2900 [1.22-1.36]

GWAS snp
PMID	[PMID 22451204 ]
Trait
Title	Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Risk Allele
P-val	8E-35
Odds Ratio	1.3800 None

[PMID 22839974 ] UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan

[PMID 15637659 ] Linkage disequilibrium patterns and tagSNP transferability among European populations.

[PMID 19771175 ] Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

[PMID 20070850 ] Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

[PMID 22425546] SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.

GWAS snp
PMID	[PMID 24511991 ]
Trait	Parkinson's disease
Title	Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
Risk Allele	T
P-val	1E-9
Odds Ratio	1.37 [1.23-1.51]

[PMID 30410434 ] A Comprehensive Analysis of the Association Between SNCA Polymorphisms and the Risk of Parkinson's Disease.

[PMID 31863812] Association between SNCA rs356220 polymorphism and Parkinson's disease: a meta-analysis.