| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
increased risk in men for biliary conditions
|
| (A;G)
|
2
|
increased risk in men for biliary conditions
|
| (G;G)
|
1
|
normal risk in men for biliary conditions
|
rs520354 is a SNP in an intron of the apolipoprotein B APOB gene; it is also known as the IVS6+360C>T variant.
In a study of ~1,000 Chinese patients with various biliary tract conditions, including cancer and gallstones, men carrying a rs520354(A) allele had a 2x risk of bile duct cancer (CI: 1.2-3.4).[PMID 18296645
]
[PMID 18252230] TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita.
[PMID 19888660] Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.
]
