rs6495306

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(G;G)	2

Make rs6495306(A;A)

Make rs6495306(A;G)

Reference

GRCh38 38.1/141

Chromosome

15

Position

78573551

Gene

CHRNA5

is a	snp
is	mentioned by
dbSNP	rs6495306
dbSNP (classic)	rs6495306
ClinGen	rs6495306
ebi	rs6495306
HLI	rs6495306
Exac	rs6495306
Gnomad	rs6495306
Varsome	rs6495306
LitVar	rs6495306
Map	rs6495306
PheGenI	rs6495306
Biobank	rs6495306
1000 genomes	rs6495306
hgdp	rs6495306
ensembl	rs6495306
geneview	rs6495306
scholar	rs6495306
google	rs6495306
pharmgkb	rs6495306
gwascentral	rs6495306
openSNP	rs6495306
23andMe	rs6495306
SNPshot	rs6495306
SNPdbe	rs6495306
MSV3d	rs6495306
GWAS Ctlg	rs6495306

GMAF

0.2764

Max Magnitude

2

?	(A;A) (A;G) (G;G)	28

Rs6495306
PubMed	[PMID 18414406]
Affy Probeset	SNP_A-8603150
Affy Orientation	reverse
On GW 5.0
Alleles A/B	C/T
Ancestral	A
Population	mixed
Allele	G
Case Freq.
Control Freq.
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All	1.43
Disease	Substance dependence, Alcohol (SD-A)

rs6495306 increases susceptibility to Substance dependence, Alcohol 1.43 times for carriers of the G allele [PMID 18414406]

[PMID 19064933] Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.

[PMID 19443489] Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

[PMID 19706762] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.