| GWAS snp
|
| PMID
|
[PMID 20372150 ]
|
| Trait
|
Birth weight
|
| Title
|
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
|
| Risk Allele
|
C
|
| P-val
|
2E-35
|
| Odds Ratio
|
0.09 [0.073-0.10] sd decrease
|
rs10049088, rs1482853, rs17451107 and rs900400 are in strong linkage disequilibrium (r2>0.93) with each other. [PMID 25244357] reports from the study itself and drawing from previous studies and meta-analysis that while rs900400 is strogly associated with birth adiposity (sum of skinfolds), that association doesn't bear over to childhood adiposity or adulthood BMI [PMID 23202124]. This somewhat remarkable because childhood adoposity is known to be associated with adverse metabolic outcomes [PMID 14710101], but according to present studies rs900400 is not responsible for them [PMID 22484627], its effects disappearing by 3 months of age [PMID 23202124].
[PMID 21307140] Variants near CCNL1/LEKR1 and in ADCY5 and Fetal Growth Characteristics in Different Trimesters
[PMID 21885063] Replication of a genome-wide association study of birth weight in preterm neonates.
[PMID 22073261] The Birth Weight Lowering C-Allele of rs900400 Near LEKR1 and CCNL1 Associates with Elevated Insulin Release following an Oral Glucose Challenge
[PMID 22685556] The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size
| GWAS snp
|
| PMID
|
[PMID 23202124]
|
| Trait
|
Birth weight
|
| Title
|
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
|
| Risk Allele
|
C
|
| P-val
|
4E-38
|
| Odds Ratio
|
.07 [0.060-0.084] gram decrease
|
[PMID 25244357] The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity
]
