rs9493857
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs9493857(A;A) |
| Make rs9493857(A;G) |
| Make rs9493857(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 134209559 |
| Gene | SGK1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs9493857 |
| dbSNP (classic) | rs9493857 |
| ClinGen | rs9493857 |
| ebi | rs9493857 |
| HLI | rs9493857 |
| Exac | rs9493857 |
| Gnomad | rs9493857 |
| Varsome | rs9493857 |
| LitVar | rs9493857 |
| Map | rs9493857 |
| PheGenI | rs9493857 |
| Biobank | rs9493857 |
| 1000 genomes | rs9493857 |
| hgdp | rs9493857 |
| ensembl | rs9493857 |
| geneview | rs9493857 |
| scholar | rs9493857 |
| rs9493857 | |
| pharmgkb | rs9493857 |
| gwascentral | rs9493857 |
| openSNP | rs9493857 |
| 23andMe | rs9493857 |
| SNPshot | rs9493857 |
| SNPdbe | rs9493857 |
| MSV3d | rs9493857 |
| GWAS Ctlg | rs9493857 |
| GMAF | 0.3669 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
10.1371/journal.pgen.1000489 The ancestral allele at rs9493857 results in increased GR-binding and glucocorticoid-regulated gene expression, suggesting that an increased stress response (i.e., glucocorticoid responsiveness) was advantageous in ancestral human populations. We speculate that, in modern times, such variation could favor the negative effects of a heightened glucocorticoid response, potentially predisposing individuals to chronic diseases such as metabolic syndrome and hypertension.
[PMID 19461886
] Adaptive variation regulates the expression of the human SGK1 gene in response to stress
