17 alpha-hydroxyprogesterone caproate

news The effectiveness of 17 alpha-hydroxyprogesterone caproate for prevention of recurrent preterm birth is influenced by SNPs.

Black women

• rs471767 homozygous for the major allele treatment significantly reduced the rate of preterm birth.
• rs578029 who had a least one copy of the major allele, treatment significantly reduced in preterm birth

non-black women

• a least one copy of the minor allele of rs503362 had a significant reduction with treatment
• with at least one copy of the minor allele of rs666553 had a significant reduction in very preterm birth