Polymorphisms in the beta-1 adrenergic receptor gene ADRB1 may explain up to 20% of the variability in how individuals respond to treatment with beta blocker drugs used to help lower blood pressure. It may also affect lipid metabolism.
Associated SNPs in the gene include:
rs1801253 may be a susceptibility polymorphism for lipid metabolism disruption. [PMID 24972470]
Dionne et al. (2002) found that the arg389 allele was associated with greater body weight with each arg389 allele being associated with a 2.91 kg greater weight.