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BAIAP2

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# SNPs11
 Max MagnitudeChromosome positionSummary
rs2858551181,036,809
rs3934492081,060,164
rs4969239081,036,744
rs4969385081,095,090
rs7210438081,086,380
rs7502931081,044,877
rs8067235081,050,837
rs8079626081,053,072
rs8079781081,076,348
rs9901648081,061,908
rs991347781,041,898

The BAIAP2 gene on chromosome 17 encodes the insulin receptor tyrosine kinase substrate protein of 53 kDa (IRSp53).

A 2016 review and meta-analysis of genetic, pharmacogenetic and biochemical studies on ADHD in adults concluded that an association was seen for the BAIAP2 gene, but no other genetic, pharmacogenetic or biochemical association was found to be significantly associated. The association between adult ADHD and several variants in the BAIAP2 gene was not observed in children.[PMID 27217152OA-icon.png]

The variants reported as being statistically significant were:

  • rs8079781; carriers of a T allele have slightly lower (0.8-0.87x) risk for adult ADHD
  • rs8079626-rs7210438, GC haplotype has slightly lower (0.8x), AC haplotype has slightly higher (1.2x), risk for adult ADHD