Chlorpropamide
From SNPedia
Chlorpropamide is a drug in the sulfonylurea class used to treat type-2 diabetes. It is a long-acting first-generation sulfonylurea. It has more side effects than other sulfonylureas and its use is no longer recommended.Wikipedia
The FDA-approved drug label for chlorpropamide (Diabinese) states that caution should be used in patients with G6PD-deficiency due to the risk for hemolytic anemia, and that a non-sulfonylurea alternative should be considered for such patients.
| Genotype/Genoset | Diplotype | Gene | Drug Use/Category/Class | Medical Field | Summary | Descriptive Sentence |
|---|---|---|---|---|---|---|
| gs309 | WT/WT | G6PD | Diabetes | Endocrinology | Normal Response Expected | You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia). |
| gs307 | Carrier | G6PD | Diabetes | Endocrinology | Consider Alternatives | You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking chlorpropamide ; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable. |
| gs308 | G6PD-deficient | G6PD | Diabetes | Endocrinology | Consider Alternatives | You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking chlorpropamide; non-sulfonylurea alternatives should be considered. |
