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Chlorpropamide

From SNPedia

Chlorpropamide is a drug in the sulfonylurea class used to treat type-2 diabetes. It is a long-acting first-generation sulfonylurea. It has more side effects than other sulfonylureas and its use is no longer recommended.Wikipedia

The FDA-approved drug label for chlorpropamide (Diabinese) states that caution should be used in patients with G6PD-deficiency due to the risk for hemolytic anemia, and that a non-sulfonylurea alternative should be considered for such patients.

PGx Table for Chlorpropamide (Diabinese)
Genotype/Genoset Diplotype Gene Drug Use/Category/Class Medical Field Summary Descriptive Sentence
gs309 WT/WT G6PD Diabetes Endocrinology Normal Response Expected You do not appear to carry any G6PD mutations linked to an unwanted side effect (hemolytic anemia).
gs307 Carrier G6PD Diabetes Endocrinology Consider Alternatives You carry a G6PD mutation that might lead to an unwanted side effect (hemolytic anemia) when taking chlorpropamide ; due to variable expression (i.e. in females), enzymatic testing for G6PD activity is advisable.
gs308 G6PD-deficient G6PD Diabetes Endocrinology Consider Alternatives You carry a G6PD mutation linked to an unwanted side effect (hemolytic anemia) when taking chlorpropamide; non-sulfonylurea alternatives should be considered.