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FAAH

From SNPedia
is agene
is mentioned by
Full namefatty acid amide hydrolase
EntrezGene2166
PheGenI2166
VariationViewer2166
ClinVarFAAH
GeneCardsFAAH
dbSNP2166
DiseasesFAAH
SADR2166
HugeNav2166
wikipediaFAAH
googleFAAH
gopubmedFAAH
EVSFAAH
HEFalMpFAAH
MyGene2FAAH
23andMeFAAH
UniProtO00519
EnsemblENSG00000117480
OMIM602935
# SNPs6
 Max MagnitudeChromosome positionSummary
rs2295632046,413,890
rs2295633046,408,711
rs324419046,406,314
rs3244202.546,405,089
rs4141964046,399,368
rs873978046,408,231


FAAH encodes fatty acid amide hydrolase an enzyme that degrades anandamide and other biological molecules. Anandamide, is an endogenous cannabinoid agonist.

Knockout mice without FAAH show reduced pain sensation and elevated anandamide. [PMID 15362158]

A fairly common FAAH gene SNP, rs324420, significantly reduces the activity of the FAAH enzyme. Studies have reported that the rs324420(A;A) genotype is generally associated with insensitivity to pain, and more specifically is associated with a reduced need for postoperative analgesia, increased postoperative nausea and vomiting induced by opioids, and decreased anxiety-linked behaviours.[PMID 30929760OA-icon.png]

In 2019, a woman was described with extreme insensitivity to pain, presumably due to co-inheriting a single rs324420(A) allele plus an 8kb microdeletion downstream of the FAAH gene that in some way appears to disrupt the function of a nearby transcribed FAAH pseudogene.[PMID 30929760OA-icon.png]