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GGPS1

From SNPedia
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# SNPs0

The GGPS1 gene on chromosome 1 encodes the geranylgeranyl diphosphate synthase 1 protein.

Acting in a dominant manner, a very rare mutation in the GGPS1 gene, GRCh37/hg19 ch1:235505746G→T (p.Asp188Tyr), is reported as likely to be the reason for bisphosphonate-related atypical femoral fractures in one group of patients presumably with osteoporosis. This mutation currently lacks a dbSNP rs-id and therefore is not in SNPedia.10.1056/NEJMc1612804

Note that the incidence of atypical femoral fractures in the general population is cited as being quite low (5.9 per 10,000 person-years).