GRIK4
| is a | gene |
| is | mentioned by |
| EntrezGene | 2900 |
| PheGenI | 2900 |
| VariationViewer | 2900 |
| ClinVar | GRIK4 |
| GeneCards | GRIK4 |
| dbSNP | 2900 |
| Diseases | GRIK4 |
| SADR | 2900 |
| HugeNav | 2900 |
| wikipedia | GRIK4 |
| GRIK4 | |
| gopubmed | GRIK4 |
| EVS | GRIK4 |
| HEFalMp | GRIK4 |
| MyGene2 | GRIK4 |
| 23andMe | GRIK4 |
| # SNPs | 6 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs12797755 | 0 | 120,938,751 | |
| rs12800734 | 0 | 120,966,045 | |
| rs1954787 | 2 | 120,792,654 | |
| rs4245040 | 0 | 120,649,920 | |
| rs534517447 | 0 | 120,956,935 | |
| rs869312699 | 0 | 120,986,102 |
The GRIK4 gene encodes a member (KA1) of the kainate-type ionotropic glutamate receptor family.
One study identified two discrete regions of disease risk within the GRIK4 locus in a Caucasian population: three SNPs and one associated haplotype indicating increased risk for schizophrenia (p=0.0005, odds ratio 1.45, CI: 1.182-1.787) and two SNPs and a haplotype associated with a protective effect against bipolar disorder (p=0.0002, odds ratio of 0.624, CI: 0.485-0.802). However, after permutation analysis to correct for multiple testing, the independent SNPs were no longer significant, and only the schizophrenia and bipolar disorder haplotypes remained significant.[PMID 16819533]
A subsequent study of 100 Japanese patients with schizophrenia that included surveys of GRIK4 found no significant association in that population.[PMID 16325263]
SNPs in rs1954787 and another gene may also influence the odds of success upon treatment with the antidepressant citalopram.[PMID 17671280]
