Heartburn
From SNPedia
Heartburn cause and treatment is discussed at Wikipedia. Heartburn may progress to acid reflux disease.
SNPs in the CYP2C19 gene, which encodes a cytochrome p450 protein responsible for breaking down some drugs (including anti-ulcer drugs like omeprazole (trade name Losec or Prilosec), esomeprazole (trade name Nexium), and lansoprazole (Prevacid) can lead to aberrant processing of these drugs and various related complications.