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From SNPedia

Heartburn cause and treatment is discussed at Wikipedia. Heartburn may progress to acid reflux disease.

SNPs in the CYP2C19 gene, which encodes a cytochrome p450 protein responsible for breaking down some drugs (including anti-ulcer drugs like omeprazole (trade name Losec or Prilosec), esomeprazole (trade name Nexium), and lansoprazole (Prevacid) can lead to aberrant processing of these drugs and various related complications.