IL1B
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | interleukin 1, beta |
| EntrezGene | 3553 |
| PheGenI | 3553 |
| VariationViewer | 3553 |
| ClinVar | IL1B |
| GeneCards | IL1B |
| dbSNP | 3553 |
| Diseases | IL1B |
| SADR | 3553 |
| HugeNav | 3553 |
| wikipedia | IL1B |
| IL1B | |
| gopubmed | IL1B |
| EVS | IL1B |
| HEFalMp | IL1B |
| MyGene2 | IL1B |
| 23andMe | IL1B |
| UniProt | P01584 |
| Ensembl | ENSG00000125538 |
| OMIM | 147720 |
| # SNPs | 15 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1143623 | 0 | 112,838,252 | |
| rs1143627 | 0 | 112,836,810 | |
| rs1143629 | 0 | 112,835,941 | |
| rs1143630 | 0 | 112,834,078 | |
| rs1143633 | 0 | 112,832,890 | |
| rs1143634 | 0 | 112,832,813 | |
| rs1143639 | 0 | 112,831,216 | |
| rs1143642 | 0 | 112,830,976 | |
| rs1143643 | 0 | 112,830,725 | |
| rs16944 | 2 | 112,837,290 | Increases susceptibility to mental illness and osteoarthritis. |
| rs2853550 | 0 | 112,829,544 | |
| rs3087258 | 0 | 112,837,294 | |
| rs3136558 | 0 | 112,833,698 | |
| rs3917345 | 0 | 112,837,577 | |
| rs3917356 | 0 | 112,834,786 |
IL1B -511 allele heterozygotes have a 4 fold higher chance of surviving bacterial meningitis than (either) homozygote [PMID 11023482]. Odds of surviving meningitis apparently further increase 2X for IL1B -511 heterozygotes who are also rs419598(T;T), i.e. homozygous for IL1RN +2018 rs419598 (T) allele (the most common one; also known as "+8006").
There does not appear to be an rs# in dbSNP for the -511 allele.
