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Insensitivity to pain

From SNPedia

Congenital insensitivity to pain, (CIP), also known as congenital analgesia, is one or more rare conditions in which a person cannot feel (and has never felt) physical pain. The conditions described here are separate from the HSAN group of disorders, which have more specific signs and etiology. Despite sounding beneficial, it is actually an extremely dangerous condition.Wikipedia

Two genes, SCN9A and PRDM12, account for most of the (quite rare) mutations reported as leading, when inherited recessively, to pain insensitivity: