KLC1
From SNPedia
is a | gene |
is | mentioned by |
EntrezGene | 3831 |
PheGenI | 3831 |
VariationViewer | 3831 |
ClinVar | KLC1 |
GeneCards | KLC1 |
dbSNP | 3831 |
Diseases | KLC1 |
SADR | 3831 |
HugeNav | 3831 |
wikipedia | KLC1 |
KLC1 | |
gopubmed | KLC1 |
EVS | KLC1 |
HEFalMp | KLC1 |
MyGene2 | KLC1 |
23andMe | KLC1 |
# SNPs | 8 |
Max Magnitude | Chromosome position | Summary | |
---|---|---|---|
rs12432907 | 0 | 103,702,041 | |
rs1799796 | 0 | 103,699,590 | |
rs28903081 | 0 | 103,698,934 | |
rs77381814 | 0 | 103,699,410 | |
rs8007903 | 0 | 103,671,306 | |
rs861537 | 0 | 103,700,738 | |
rs861539 | 0 | 103,699,416 | |
rs8702 | 0 | 103,686,015 |
Variants in the kinesin light-chain 1 KLC1 gene has potentially been implicated in a wide variety of conditions, including Alzheimer's disease, multiple sclerosis, cataracts, and leukoaraiosis.
- rs8702: observed in connection to both multiple sclerosis and Alzheimer's disease
- A study of 100 patients with Alzheimer's disease found an association with the C allele of the KCL1 intron 13 SNP, G56836, with odds ratio = 1.73, CI: 1.12-2.67, p = 0.012. No synergistic effects were found between the ApoE4 allele and KCL1 gene polymorphisms.[PMID 15364413]
SNPs observed in connection to leukoaraiosis (LA) include:
- A SNP known as the G56836C variant, located in intron 13. An association analysis performed in 229 patients with LA found that the 56836(C;C) variant increased the risk of LA 7.76-fold in hypertensive smokers as compared with those not carrying this variant.[PMID 17917076, PMID 17977659]