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Kidney cancer

From SNPedia

More formally known as renal cancer or renal cell carcinoma (RCC), there are four primary forms of inherited kidney cancer:

  • Von Hippel Lindau (VHL) for clear cell RCC, based on mutations in the VHL gene;
    • VHL clinical features include tumors developing in both kidneys, adrenal glands, pancreas, brain or spine, eyes, or inner ears.
  • hereditary papillary renal carcinoma for type 1 papillary RCC, based on mutations in the MET gene;
  • Birt Hogg Dube for chromophobe RCC, based on mutations in the FLCN gene;
  • hereditary Leiomyomatosis renal cell carcinoma for type 2 papillary RCC, based on mutations in the FH gene.