Multiple myeloma
At a minimum, these SNPs are known to be related, and others may also be
Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. In multiple myeloma, collections of abnormal plasma cells accumulate in the bone marrow, where they interfere with the production of normal blood cells.Wikipedia
A large study published in 2016 including a meta-analysis and a new GWA study confirmed 9 reported SNPs and discovered 8 new ones [PMID 27363682]; note that most effects are fairly small, with almost all odds ratios under 1.25. Listed with their risk alleles - based on hg19 plus strand, not necessarily as in dbSNP or SNPedia - as published are:
The 9 replicated (first SNP is as originally published; second SNP is proxy from this study):
- rs6746082(A)/rs7577599(T)
- rs1052501(C)/rs6599192(G)
- rs4487645(C)
- rs10936599(C)/rs10936600(A)
- rs2285803(T)/rs3132535(A)
- rs4273077(G)/rs34562254(A)
- rs877529(A)/rs139402(C)
- rs56219066(T)/rs1423269(A)
- rs138740(C)/rs138747(A)
The 8 new SNPs:
