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From SNPedia

NyQuil is the brand name for a group of cold medicines; they typically contain analgesics (acetaminophen), antihistamines (Doxylamine succinate), and cough suppressants (dextromethorphan).

SNPs in genes that encode proteins that metabolize these drugs may influence how a person responds to products like NyQuil.

For example, SNPs in the CYP2D6 gene affect the metabolism of dextromorphan.