Personality is hard to define, but we think we know it when we see it. Interestingly, wikipedia doesn't at present have a general article on this topic, but instead only a disambiguation page to various aspects. At SNPedia we're using this page to identify some of the SNPs which have been reported to influence personality; the statistics behind these publications are often weak, so, caveat emptor.
- rs4680 warrior vs worrier
- rs53576 influences social behavior and personality
- rs6311 serotonin-related
- rs6313 serotonin-related
- rs25531 response to negative emotional stimulus
- rs4623951 anxiety and memory
A GWAS study published in 2017 found eight SNPs associated with personality traits and some correlation with psychiatric disorders [PMID 27918536
]; the eight SNPs (six of which were more significant statistically) were:
- rs3814424 (conscientiousness)
- rs57590327 (extraversion)
- rs2164273 (extraversion)
- rs6481128 (extraversion)
- rs1426371 (extraversion)
- rs7498702 (extraversion)
- rs6981523 (neuroticism)
- rs9611519 (neuroticism)
Research published in [Nature] investigated SNPs near EVL, CROT, and other genes that may be associated with hostility (anger, cynicism, and paranoia):
