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From SNPedia

Geno Mag Summary
(C;C) higher risk for RA
(C;T) higher risk for RA
(T;T) 2.1 depression, panic, stress response
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs6313
1000 genomesrs6313
GWAS Ctlgrs6313
Max Magnitude2.1
? (C;C) (C;T) (T;T) 28

rs6313, also known as T102C, is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6313(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). [PMID 18006541]

Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.

see also gs108 and gs226

[PMID 19387614] HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients

[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression

[PMID 19897250] An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population

[PMID 19647026] Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes

[PMID 20431430] The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness

[PMID 17440930] Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder.

[PMID 20827275] Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects

[PMID 21089166OA-icon.png] Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis

[PMID 21089121] Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis

[PMID 21969281] Influence of birth weight on internalizing traits modulated by serotonergic genes

[PMID 15882913] The KPNA3 gene may be a susceptibility candidate for schizophrenia.

[PMID 16272956] CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents.

[PMID 16642436OA-icon.png] Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.

[PMID 17000047] Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder.

[PMID 17521439OA-icon.png] Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.

[PMID 17590256] 5-HT2A SNPs and the Temperament and Character Inventory.

[PMID 17601350OA-icon.png] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 17964050] Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients.

[PMID 18191318] Association study between obsessive-compulsive disorder and serotonergic candidate genes.

[PMID 18196244] Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.

[PMID 18712714OA-icon.png] Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.

[PMID 18797395] Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts.

[PMID 18801406] Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression.

[PMID 19184136OA-icon.png] Examination of association of genes in the serotonin system to autism.

[PMID 19197363OA-icon.png] A genome-wide investigation of SNPs and CNVs in schizophrenia.

[PMID 19379518OA-icon.png] Development of a fingerprinting panel using medically relevant polymorphisms.

[PMID 19545856OA-icon.png] Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.

[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

[PMID 19742166OA-icon.png] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

[PMID 19937159] HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.

[PMID 20008943OA-icon.png] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

[PMID 20403506OA-icon.png] Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.

[PMID 20565774OA-icon.png] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

[PMID 21136126] Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.

[PMID 21162693OA-icon.png] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.

[PMID 21320838] Variations in 5-HT2A influence spatial cognitive abilities and working memory.

[PMID 21621273OA-icon.png] Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.

[PMID 21930285OA-icon.png] The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients.

[PMID 22545912] Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population.

[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy

[PMID 23245538] Association of candidate gene polymorphisms with diastolic blood pressure change in patients treated with duloxetine

[PMID 22735397] Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner.

[PMID 22751492] Family-based study of HTR2A in suicide attempts: observed gene, gene x environment and parent-of-origin associations.

[PMID 23321485OA-icon.png] The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment.

[PMID 23397970OA-icon.png] Interpersonal and genetic origins of adult attachment styles: a longitudinal study from infancy to early adulthood.

[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.

[PMID 25174699] Serotonin Receptor Gene (5HT-2A) Polymorphism is Associated with Provoked Vestibulodynia and Comorbid Symptoms of Pain

[PMID 25069264] [Haplotype analysis of serotonin 2A receptor gene polymorphisms and smoking behavior]

[PMID 25758572OA-icon.png] 5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia

[PMID 25853073OA-icon.png] Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays

[PMID 26544898] The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment - a European multicentre study

[PMID 26557070OA-icon.png] Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals' perspective taking ability and autistic-like traits

[PMID 27325396] Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson's disease patients.

[PMID 29120849OA-icon.png] Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.

[PMID 29602729] Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A.

[PMID 30738094] Genetic variants as risk factors for cigarette smoking at an early age and relapse to smoking cessation treatment: A pilot study.