rs6313

minus

Geno	Mag	Summary
(C;C)		higher risk for RA
(C;T)		higher risk for RA
(T;T)	2.1	depression, panic, stress response

Reference

GRCh38 38.1/141

Chromosome

13

Position

46895805

Gene

HTR2A

is a	snp
is	mentioned by
dbSNP	rs6313
dbSNP (classic)	rs6313
ClinGen	rs6313
ebi	rs6313
HLI	rs6313
Exac	rs6313
Gnomad	rs6313
Varsome	rs6313
LitVar	rs6313
Map	rs6313
PheGenI	rs6313
Biobank	rs6313
1000 genomes	rs6313
hgdp	rs6313
ensembl	rs6313
geneview	rs6313
scholar	rs6313
google	rs6313
pharmgkb	rs6313
gwascentral	rs6313
openSNP	rs6313
23andMe	rs6313
SNPshot	rs6313
SNPdbe	rs6313
MSV3d	rs6313
GWAS Ctlg	rs6313

GMAF

0.4288

Max Magnitude

2.1

?

(C;C) (C;T) (T;T)

28

rs6313, also known as T102C, is part of a 4-SNP haplotype in the serotonin 2A receptor gene HTR2A that has been associated with rheumatoid arthritis in a study of 1800 European patients. The risk allele is rs6313(C). The overall risk for the haplotype CTCC of SNPs rs6311-rs1328674-rs6313-rs6314 is 1.68 (CI: 1.20 - 2.34, p = 0.02). [PMID 18006541]

Note: the orientation of rs1328674 in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.

see also gs108 and gs226

[PMID 19387614] HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients

[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression

[PMID 19897250] An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population

[PMID 19647026] Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes

[PMID 20431430] The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness

[PMID 17440930] Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorder.

[PMID 20827275] Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects

[PMID 21089166 ] Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis

[PMID 21089121] Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis

[PMID 21969281] Influence of birth weight on internalizing traits modulated by serotonergic genes

[PMID 15882913] The KPNA3 gene may be a susceptibility candidate for schizophrenia.

[PMID 16272956] CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents.

[PMID 16642436 ] Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment.

[PMID 17000047] Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder.

[PMID 17521439 ] Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach.

[PMID 17590256] 5-HT2A SNPs and the Temperament and Character Inventory.

[PMID 17601350 ] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 17964050] Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients.

[PMID 18191318] Association study between obsessive-compulsive disorder and serotonergic candidate genes.

[PMID 18196244] Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.

[PMID 18712714 ] Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density schizophrenia families.

[PMID 18797395] Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts.

[PMID 18801406] Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression.

[PMID 19184136 ] Examination of association of genes in the serotonin system to autism.

[PMID 19197363 ] A genome-wide investigation of SNPs and CNVs in schizophrenia.

[PMID 19379518 ] Development of a fingerprinting panel using medically relevant polymorphisms.

[PMID 19545856 ] Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.

[PMID 19693267 ] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

[PMID 19742166 ] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

[PMID 19937159] HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.

[PMID 20008943 ] Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.

[PMID 20403506 ] Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study.

[PMID 20565774 ] Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

[PMID 21136126] Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.

[PMID 21162693 ] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

[PMID 21172166 ] Pharmacogenetics of antidepressant response.

[PMID 21320838] Variations in 5-HT2A influence spatial cognitive abilities and working memory.

[PMID 21621273 ] Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.

[PMID 21930285 ] The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients.

[PMID 22545912] Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population.

[PMID 23499153] Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy

[PMID 23245538] Association of candidate gene polymorphisms with diastolic blood pressure change in patients treated with duloxetine

[PMID 22735397] Serotonin system gene polymorphisms are associated with impulsivity in a context dependent manner.

[PMID 22751492] Family-based study of HTR2A in suicide attempts: observed gene, gene x environment and parent-of-origin associations.

[PMID 23321485 ] The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment.

[PMID 23397970 ] Interpersonal and genetic origins of adult attachment styles: a longitudinal study from infancy to early adulthood.

[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.

[PMID 25174699] Serotonin Receptor Gene (5HT-2A) Polymorphism is Associated with Provoked Vestibulodynia and Comorbid Symptoms of Pain

[PMID 25069264] [Haplotype analysis of serotonin 2A receptor gene polymorphisms and smoking behavior]

[PMID 25758572 ] 5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia

[PMID 25853073 ] Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays

[PMID 26544898] The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in depressed patients with insufficient response to treatment - a European multicentre study

[PMID 26557070 ] Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals' perspective taking ability and autistic-like traits

[PMID 27325396] Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson's disease patients.

[PMID 29120849 ] Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.

[PMID 29602729] Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A.

[PMID 30738094] Genetic variants as risk factors for cigarette smoking at an early age and relapse to smoking cessation treatment: A pilot study.