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STAT3

From SNPedia
is agene
is mentioned by
ClinVarSTAT3
GeneCardsSTAT3
DiseasesSTAT3
wikipediaSTAT3
googleSTAT3
gopubmedSTAT3
EVSSTAT3
HEFalMpSTAT3
MyGene2STAT3
23andMeSTAT3
# SNPs55
 Max MagnitudeChromosome positionSummary
rs102691642,377,817
rs1053004042,314,074
rs1053005042,313,892
rs1053023042,313,598
rs1057520377042,325,013
rs1057521091042,325,030
rs1064793452042,337,520
rs1064794421042,322,412
rs1064794899042,323,046
rs1064794957042,317,182
rs1064796762042,323,264
rs1064796922042,322,440
rs1085307931042,333,730
rs113994135042,329,643
rs113994136042,329,642
rs113994137042,329,423
rs113994138042,325,038
rs113994139042,322,474
rs1294254742,375,526
rs1295197142,376,113
rs1759322242,360,972
rs193922716042,333,719
rs193922717042,329,448
rs193922719042,323,120
rs193922720042,323,112
rs193922721042,322,413
rs193922722042,317,192
rs229128142,346,443
rs229128242,346,547
rs229315242,329,511
rs2306580042,339,662
rs381676942,346,255
rs397514766042,329,621
rs479679342,390,192
rs587777647042,316,896
rs587777648042,329,612
rs587777649042,322,445
rs587777650042,322,409
rs650369542,347,515
rs721177742,382,057
rs74416642,362,183
rs769031989042,322,464
rs786205503042,323,024
rs806964542,342,884
rs869312887042,333,690
rs869312888042,329,430
rs869312889042,322,395
rs869312890042,339,328
rs869312891042,331,524
rs869312892042,316,899
... further results

A member of the STAT protein family, the STAT3 gene on chromosome 17 encodes a transcription factor that plays a critical role in mediating cytokine-induced changes in gene expression.Wikipedia

Loss-of-function mutations in the STAT3 gene result in Hyperimmunoglobulin E syndrome, also known as Job syndrome, which is associated with recurrent infections as well as disordered bone and tooth development. These mutations are rare, and can be dominantly inherited or can be de novo.

Gain-of-function mutations in the STAT3 gene have been reported to cause multi-organ early onset auto-immune diseases; such as thyroid disease, diabetes, intestinal inflammation, and low blood counts, while constitutive STAT3 activation is associated with various human cancers and commonly suggests poor prognosis.