STAT3

is a	gene
is	mentioned by
ClinVar	STAT3
GeneCards	STAT3
Diseases	STAT3
wikipedia	STAT3
google	STAT3
gopubmed	STAT3
EVS	STAT3
HEFalMp	STAT3
MyGene2	STAT3
23andMe	STAT3
# SNPs	55

	Max Magnitude	Chromosome position
rs1026916	0	42,377,817
rs1053004	0	42,314,074
rs1053005	0	42,313,892
rs1053023	0	42,313,598
rs1057520377	0	42,325,013
rs1057521091	0	42,325,030
rs1064793452	0	42,337,520
rs1064794421	0	42,322,412
rs1064794899	0	42,323,046
rs1064794957	0	42,317,182
rs1064796762	0	42,323,264
rs1064796922	0	42,322,440
rs1085307931	0	42,333,730
rs113994135	0	42,329,643
rs113994136	0	42,329,642
rs113994137	0	42,329,423
rs113994138	0	42,325,038
rs113994139	0	42,322,474
rs12942547	0	42,375,526
rs12951971	0	42,376,113
rs17593222	0	42,360,972
rs193922716	0	42,333,719
rs193922717	0	42,329,448
rs193922719	0	42,323,120
rs193922720	0	42,323,112
rs193922721	0	42,322,413
rs193922722	0	42,317,192
rs2291281	0	42,346,443
rs2291282	0	42,346,547
rs2293152	0	42,329,511
rs2306580	0	42,339,662
rs3816769	0	42,346,255
rs397514766	0	42,329,621
rs4796793	0	42,390,192
rs587777647	0	42,316,896
rs587777648	0	42,329,612
rs587777649	0	42,322,445
rs587777650	0	42,322,409
rs6503695	0	42,347,515
rs7211777	0	42,382,057
rs744166	0	42,362,183
rs769031989	0	42,322,464
rs786205503	0	42,323,024
rs8069645	0	42,342,884
rs869312887	0	42,333,690
rs869312888	0	42,329,430
rs869312889	0	42,322,395
rs869312890	0	42,339,328
rs869312891	0	42,331,524
rs869312892	0	42,316,899
... further results

A member of the STAT protein family, the STAT3 gene on chromosome 17 encodes a transcription factor that plays a critical role in mediating cytokine-induced changes in gene expression.Wikipedia

Loss-of-function mutations in the STAT3 gene result in Hyperimmunoglobulin E syndrome, also known as Job syndrome, which is associated with recurrent infections as well as disordered bone and tooth development. These mutations are rare, and can be dominantly inherited or can be de novo.

Gain-of-function mutations in the STAT3 gene have been reported to cause multi-organ early onset auto-immune diseases; such as thyroid disease, diabetes, intestinal inflammation, and low blood counts, while constitutive STAT3 activation is associated with various human cancers and commonly suggests poor prognosis.