Talk:Rs1045642(T;T)
From SNPedia
With the increasing incidence of coronary artery disease, knowledge of variations in anticoagulant metabolism may have in impact on drug therapy. This is particularly important in those undergoing stent placement. Variants in the CYP2C19 gene affect how people metabolize clopidogrel and those that those who metabolize clopidogrel faster were less likely to develop early stent thrombosis.
ABCB1 gene encodes a protein that effects clopidogrel absorption; rs individuals with the AA genotype at rs1045642 in the ABCB1 gene had 2.6 times higher odds of developing early stent thrombosis over individuals with the AG or GG genotypes.
