Talk:Rs7330796

Sources like http://medicalxpress.com/news/2014-06-scientists-genetic-code-diabetes-greenland.html quote the researchers with "The gene variant is only found in Greenlanders and explains 15% of cases of diabetes in the country". However, as can be seen the HapMap data shows the variant is present everywhere, and even 1000 Genomes lists MAF as 0.258 - much higher than the apparent Greendland MAF of 17%. So I'm not really sure what's going on here. On the other hand genotyping beadchips don't generally test for it (So why does HapMap have it?), but it can be imputed. --Donwulff (talk) 15:42, 23 June 2014 (UTC)

I believe rs61736969 is the snp you are looking for. --- cariaso 16:50, 23 June 2014 (UTC)

Thanks, that makes a LOT more sense. I checked again, rs7330796 was the discovery SNP they used with a chip able to genotype it which is why it's plastered all over the study, then sequenced a few of the individuals to hone in on the causal variant, rs61736969. They're in very high LD, meaning inherited together, but not everybody with one has the other. [1] Unfortunately most of the linked SNP's aren't tested by current OTC companies, rs1062087 is one though. Probably should delete this wrong SNP entirely, or just make it "See rs61736969", causing an endless loop. --Donwulff (talk) 18:08, 23 June 2014 (UTC)