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From SNPedia

Tuberculosis (TB) is an infectious disease usually caused by the Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body. Most infections do not have symptoms, in which case it is known as latent tuberculosis. About 10% of latent infections progress to active disease which, if left untreated, kills about half of those infected. The classic symptoms of active TB are a chronic cough with blood-containing sputum, fever, night sweats, and weight loss.Wikipedia

Several variants have been reported to increase a person's risk of developing tuberculosis if exposed to the TB bacterium, most have minor impact (odds ratios less than 2), but at least one is quite significant:

  • rs34536443, leading to almost a 100-fold increase in risk