| ||Max Magnitude||Chromosome position||Summary|
The ZFYVE26 gene, located on chromosome 14, encodes a protein called spastizin. When first described, this gene was named KIAA0321.
Eight (somewhat overlapping) roles have been described for spastizin, according to a 2017 literature summary.
Recessively inherited mutations in the ZFYVE26 gene may lead to a motor neuron disease considered to be form of spastic paraplegia, type 15, and thus known as SPG15.
The UK-based "Save Our Maddi" campaign seeks to raise awareness of SPG15 and to encourage the development of gene therapies to treat the disease.