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DPYD

From SNPedia

is agene
is mentioned by
Full namedihydropyrimidine dehydrogenase
EntrezGene1806
PheGenI1806
VariationViewer1806
ClinVarDPYD
dbSNP1806
SADR1806
HugeNav1806
wikipediaDPYD
googleDPYD
gopubmedDPYD
EVSDPYD
HEFalMpDPYD
MyGene2DPYD
23andMeDPYD
UniProtQ12882
EnsemblENSG00000188641
OMIM612779
# SNPs36
 Max MagnitudeChromosome positionSummary
rs1116584697,354,111
rs11185827697,549,600
rs11276620397,305,279
rs115232898097,699,474
rs1158787397,187,514
rs13799909097,373,598
rs13861637997,450,189
rs14104403697,082,365
rs14398639897,740,439
rs14577386397,450,187
rs176021797,137,438
rs1801159097,515,839
rs18011603.597,305,364
rs1801265097,883,329
rs180126697,691,776
rs1801267097,098,598
rs180126897,079,071
rs18310578297,595,107
rs18338577097,593,322
rs2297595097,699,535
rs39182903.597,450,058
rs5567443297,098,616
rs558860623.597,515,787
rs5908605597,450,190
rs668585997,357,213
rs673767983.597,082,391
rs7254760197,079,121
rs72547602097,079,133
rs7254930497,549,609
rs7254930797,699,399
rs7254930897,699,430
rs72549310097,883,353
rs753113897,457,943
rs755095997,461,283
rs773499329097,373,561
rs82805497,144,470


The Dihydropyrimidine dehydrogenase DPYD gene encodes the enzyme of that same name, a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. SNPs leading to deficiency of this enzyme result in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients undergoing chemotherapy using fluoropyrimidines such as 5-fluorouracil. Wikipedia

SNPs in the DPYD gene that influence chemotherapeutic toxicity include:

Note that SNPs in several other genes may influence chemotherapeutic toxicity, including the TYMS gene, which encodes the enzyme that is the primary target of 5-fluorouracil.