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From SNPedia

Magnitude 5
Repute Bad
Summary DR3/4-DQ8 individual at high risk for type-1 diabetes
Criteria Gs121/criteria

This genoset identifies the DR3/4-DQ8 genotype based on SNPs rs2040410 and rs7454108; DR3/4-DQ8 individuals with family histories have a risk of over 50% for developing type-1 diabetes. [PMID 18694972]