Have questions? Visit https://www.reddit.com/r/SNPedia


From SNPedia

Magnitude 3.5
Repute Bad
Summary Poor warfarin metabolizer
Criteria Gs126/criteria

Approximately 7-10% of people are poor metabolizers of the popular anticoagulant Warfarin and would probably need a decreased dosage. This due to mutations in rs1799853 or rs1057910 causing an inactive CYP2C9 gene. You are at increased risk of drug-induced side effects due to diminished drug elimination. Prodrugs dependent on CYP2C9 metabolism may fail to generate the active form of the drug.