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From SNPedia

Magnitude 3.5
Repute Bad
Summary CYP2C19 Poor Metabolizer
Criteria Gs152/criteria
CYP2C19 Poor Metabolizer. Your body breaks down some medicines more slowly than most people. As a result, you may need a lower than average dosage of the medicines metabolized by CYP2C19 in order to decrease adverse effects, or a higher than average dose to increase efficacy of drugs that require metabolization by CYP2C19 to become active.

One example of a drug requiring bioconversion by CYP2C19 is Clopidogrel (Plavix); CYP2C19 poor metabolizers may require higher Clopidogrel dosing or the use of another thienopyridine such as prasugrel.[1]